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Abstract

Bioactives Profile of Purple and Black Tomato: Potential Applications in the Pharmaceutical Field Purple and Black Tomato

Author(s): SIMONE PERNA, SHERRY NASRALLA TAWFIK, T.ARIQ A. ALALWAN, CLARA GASPARRI, GABRIELLA PERONI, ZAHRAA ALAALI, HIND MUBARAK, EBTISAM BIN BUTTI, MONA A. AZIZ ALJAR, VITTORIA INFANTINO, MARIANGELA RONDANELLI
Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O. Box 32038 Kingdom of Bahrain, 2Pharmacy Program, Pharmacology Stream, Allied Health Department, College of Health Sciences, University of Bahrain, Manama P.O. Box 32038, Kingdom of Bahrain; 3Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona Istituto Santa Margherita, University of Pavia, Pavia, 27100 Italy; 4Department of Chemistry, College of Science, University of Bahrain, Sakhir Campus P. O. Box 32038 Kingdom of Bahrain; 5Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia,27100 Italy

Correspondence Address:
GABRIELLA PERONI, Pharmacy Program, Pharmacology Stream, Allied Health Department, College of Health Sciences, University of Bahrain, Manama P.O. Box 32038, Kingdom of Bahrain, E-Mail: gabriella.peroni01universitadipavia.it


The purple and black tomato are sources of different antioxidants such as carotenoids and flavonoids that seem to have dose-dependent antioxidant, anti-inflammatory, anti-proliferative and hypnotic effects. The aim of this review is to discuss their advantageous role in health promotion and prophylaxis against chronic conditions induced by inflammation and oxidative stress. Data research was conducted on five major databases using specific keywords to extract relevant articles. The anti-proliferative effect was seen in a deep purple tomato in two human cancer cell lines: human colorectal adenocarcinoma cell line and HeLa cell line. Potential anticancer properties were attributed to radical scavenging activity, enzyme detoxification, reduced cell proliferation, angiogenesis and invasiveness. Ingestion of purple and black tomato seeds was proven to increase circulating melatonin levels and improve hypnosis. Purple and black tomato anthocyanin treatment was also significantly associated with increased sperm motility and spermatogenic cell density. The high content of bioactives in purple and black tomato may find application in prevention of cancer and cardiovascular diseases as well as management of sleep and fertility disorders.

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