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Abstract

Bioactivity Enhanced Isolated Carpaine from Carica papaya Leaves for Platelet Stimulating Activity

Author(s): V. S. Tambe*, D. D. Waichal and R. R. Chanshetty
Department of Quality Assurance Techniques, PES Modern College of Pharmacy (For Ladies), Moshi, Pune, Maharashtra 412105, India

Correspondence Address:
V. S. Tambe, Department of Quality Assurance Techniques, PES Modern College of Pharmacy (For Ladies), Moshi, Pune, Maharashtra 412105, India, E-mail: [email protected]


Carica papaya leaves are used in folklore medicine for the treatment of different types of thrombocytopenia associated with diseases and drugs. There are several scientific studies carried out on humans and animal models to confirm the efficacy of papaya leaves extract for the treatment of thrombocytopenia. In the present study, the alkaloid, carpaine extracted from papaya leaves was found to have platelet stimulating activity. Papaya leaves powder was extracted by microwave with a mixture of methanol: glacial acetic acid: water (180:2:1.6 v/v/v). The extract was treated with suitable solvent to obtain alkaloid fraction. From the total alkaloids, carpaine was further separated by preparative thin layer chromatography, purified and analyzed. Carpaine was complexed with beta-cyclodextrin and mixed with piperine. The complex was administered in thrombocytopenia induced rats. The results showed that bioavailability enhanced carpaine exhibits potent activity of increasing platelet count.

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