All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Bioavailability Of Puerarin-Phospholipid Solid Dispersion In Rats

Author(s): Guangxi Zhai, Hongxiang Lou, Dianzhou Bi, Lijia Zou

The purpose of this investigation is to evaluate the bioavailability in rats after oral administration of puerarin or puerarin-phospholipid solid dispersion. A simple and sensitive HPLC method was developed for determination of puerarin in rat plasma. It was shown that its plasma concentration reached a peak of 0.35 μg/ml at 0.64 h after oral administration (50 mg/kg). However, after intake of puerarin-phospholipid solid dispersion, a peak of 0.78 μg/ml occurred at a later time, 1.06 h. There was a significant difference in the mean area under the concentration-time curves (AUC)between the free drug and the puerarin-phospholipid solid dispersion.

PDF

 
 
List of Supporting Conferences