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Abstract

Bioavailability Studies Of Paracetamol Bioadhesive Tablets

Author(s): Y Madhusudan Rao, G Vani, R. B. R Chary

Tablets of paracetamol control (plain), layered with bioadhesive polymer, HPMC K4M on one side and matrix tablets with the same polymer were prepared and tested for their bioavailability in normal, healthy male human volunteers in a randomised crossover study. Paracetamol in serum was estimated by a HPLC method with salicylamide as internal standard. The results indicate significant differences in mucoadhesive matrix type tablet with respect to pharmacokinetic parameters, Tmax, AUC and MRT. The study also indicated considerably higher bioavailability from these tablets with better therapeutic efficiency.

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