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Abstract

Bioinformatics Analysis of the Role of I Kappa B Kinase Interacting Protein in the Progression and Immunity of Lower-Grade Glioma in the Brain

Author(s): Jing Fan, Ying Hong Hu and Reng Ren*
Department of Neurointensive Care, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhengjiang Province 310009, China

Correspondence Address:
Reng Ren, Department of Neurointensive Care, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhengjiang Province 310009, China, E-mail: renreng1203@zju.edu.cn


Using the Cancer Genome Atlas database, we downloaded sequencing ribonucleic acid data from low-grade glioma tissues and normal tissues and analyzed them further. First, we analyzed the exposure of I kappa B kinase interacting protein in pan-cancer. We further analyzed the differential representation of I kappa B kinase interacting protein in normal tissues and low-grade gliomas. Survival analysis showed the connection between I kappa B kinase interacting protein exposure and clinical survival. In addition, we performed I kappa B kinase interacting protein correlation analysis and selected the fifty genes with the highest relevance for heat mapping. Gene set enrichment analysis illustrated the pathways associated with I kappa B kinase interacting protein. Finally, we analyzed the immune microenvironment of the tumor and drew a lollipop map. Pan-cancer analysis showed that I kappa B kinase interacting protein was differentially expressed in 25 tumors, including adrenocortical carcinoma and bladder urothelial carcinoma. I kappa B kinase interacting protein was highly expressed in low-grade gliomas. Survival analysis showed that I kappa B kinase interacting protein high expression group performed poorly in terms of overall survival, disease-specific survival and progression-free interval. Gene set enrichment analysis revealed that I kappa B kinase interacting protein was expressed in Reactome signaling of Ras homologous GTPase and Reactome signaling of interleukins. Immune microenvironment analysis showed that immune cells such as Th2 cells, T helper cells and DC were distinctly distinguished between the high and low-I kappa B kinase interacting protein-expressing groups. I kappa B kinase interacting protein is highly expressed in low-grade gliomas and affects the prognosis and immunity of low-grade gliomas.

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