Biovailability of nitrofurantion from multiple w/o/w emulsions in man and the influence of the oil phase of the emulsion.
Dept. of Pharmaceutics Faculty of Pharmacy, Obafemi Awolow University, lle-lfe, Nigeria
C O Onyeji Dept. of Pharmaceutics Faculty of Pharmacy, Obafemi Awolow University, lle-lfe, Nigeria
Eight healthy volunteers had an oral administration of a single 100mg dose of nitrofurantoin in tablet dosage form and water-in-oil-water(w/o/w)emulsions in a crossover fashion.The bioavailability of the drug was evaluated from the urinary excretion data of the unchanged drug. The extent of absorption and the periods of maintenance of the minimum effective urine concentration (MEUC) following absorption of the drug from the Soyabean oil-w/o/w emulsion were both significantly higher (p < 0.05) compared to the corresponding values for the archis oil-w/o/w emulsion. Also the same values for the tablet dosage form were lowest (p < 0.05). On the other hand, the rates of absorption of the drug from the different dosage forms showed no significant differences (p < 0.05). From the results of this study, it could be suggested that oral administration of the nitrofurantoin in the form of w/o/w emulsions could improve its bioavailability and therapeutic efficacy. Also, the nature of the oil phase of the emulsion is important in determining the extent of nitrofurantoin absorption.PDF