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Ceftriaxone - Induced Lipid Peroxidation And Its Inhibition with Various Antioxidants

Author(s): K Roy, A. U De, Chandana Sengupta

Comparative studies on possible in vitro suppressive actions of three antioxidants, ascorbic acid (AA), cysteine hydrochloride (CH) and hydroquinone (HQ) on ceftriaxone sodium (CTS)-induced lipid peroxidation were performed using goat whole blood as the lipid source to explore possible potential of the antioxidants to reduce the drug-induced toxicities. AA was found to significantly suppress CTS -induced lipid peroxidation while CH and HQ failed to do so. Lipid peroxidation being a toxicity mediating process, AA might have potential to reduce the toxic effects of CTS on co-administration in vivo.


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