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Cellulose acetate pathalate matrix in naf tablets.

Author(s): KS Aithal, N Udupa
College of Pharmaceutical Sciences,K.M.C., Manipal-576 119,

Correspondence Address:
K S Aithal College of Pharmaceutical Sciences,K.M.C., Manipal-576 119

The formulation of NaF tablets using Cellulose Acetate Phthalate (CAP) as matrix material, with an intention to prepare slow release buccal tablets for the prevention of dental caries is developed. Various micrometric studies of granules and tablets (containing different concentrations of CAP are studied. Dissolution studies are also carried out in distilled water at 37 +/- 1 degree. Significant variations in granule and tablet) parameters depending upon the concentration of CAP is observed. The in-vitro drug release reveals that T80 percent values are above 90 min for formulations containing more than 30 percent CAP. The drug dissolution is diffusion controlled and follow the Higuchi equation. The fraction of the drug release is proportional to time 1/2. Preliminary clinical data will also be discussed.


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