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Abstract
Central nervous system depressant activity of cinnamic acid derivatives
Author(s): M NA Rao, PN Ramanan, DR Kulkarni
College of Pharmaceutical Sciences,Dept. Pharmacology, K.M.C., Manipal 576 119
Correspondence Address:
M NA Rao College of Pharmaceutical Sciences,Dept. Pharmacology, K.M.C., Manipal 576 119
College of Pharmaceutical Sciences,Dept. Pharmacology, K.M.C., Manipal 576 119
Correspondence Address:
M NA Rao College of Pharmaceutical Sciences,Dept. Pharmacology, K.M.C., Manipal 576 119
Fourteen cinnamic acid derivatives with substitution in the phenyl ring were tested for CNS depressant activity by prolongation of pentobarbitone induced sleep. Halogenated cinnamic acids showed significant activity. QSAR by regression analysis showed that hydrophobicity of the substituents is importent for activity. All the cinnamic acids studied are present in ionized form at physiological pH.
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