Abstract

In this study, α-mangostin, extracted from mangosteen peel, was developed in to a topical film-forming gel antiacne preparation using different film-forming polymers as carriers. The physicochemical properties and α-mangostin incorporation efficiency were evaluated. In vitro permeation of α-mangostin-loaded film-forming gels, antibacterial activity against Propionibacterium acnes and Staphylococcus aureus were examined. The optimal formulations were viscous gels, which could convert into a dry film within 30 min after application. The films were transparent, flexible and easy to peel off. Scanning electron micrographs of the α-mangostin-loaded film-forming gels revealed a rough surface with an interior porous structure while blank film-forming gels showed smooth and compact morphology. The high α-mangostin incorporation efficiency up to 96 % was achieved. In vitro permeation studies showed a biphasic permeation profile with a fast permeation characteristic within 30 min followed by a slow permeation up to 8 h. α-Mangostinloaded film-forming gels demonstrated efficient antibacterial activities against P. acnes and S. aureus. Moreover, α-mangostin-loaded film-forming gels showed good physicochemical stability during storage at 4º for 6 mo. In summary, the developed α-mangostin-loaded film-forming gels are good candidates for topical antiacne treatments.