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Characterization and Evaluation of ?-Mangostin-loaded Film-forming Gels for Acne Treatment

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, 1Department of Microbiology and Parasitology, Faculty of Medical Sciences, 2The Center of Excellence in Medical Biotechnology, Naresuan University, Phitsanulok, 3The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education, Bangkok, Thailand

Correspondence Address:
The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education, Bangkok, Thailand, E-mail:

In this study, α-mangostin, extracted from mangosteen peel, was developed in to a topical film-forming gel antiacne preparation using different film-forming polymers as carriers. The physicochemical properties and α-mangostin incorporation efficiency were evaluated. In vitro permeation of α-mangostin-loaded film-forming gels, antibacterial activity against Propionibacterium acnes and Staphylococcus aureus were examined. The optimal formulations were viscous gels, which could convert into a dry film within 30 min after application. The films were transparent, flexible and easy to peel off. Scanning electron micrographs of the α-mangostin-loaded film-forming gels revealed a rough surface with an interior porous structure while blank film-forming gels showed smooth and compact morphology. The high α-mangostin incorporation efficiency up to 96 % was achieved. In vitro permeation studies showed a biphasic permeation profile with a fast permeation characteristic within 30 min followed by a slow permeation up to 8 h. α-Mangostinloaded film-forming gels demonstrated efficient antibacterial activities against P. acnes and S. aureus. Moreover, α-mangostin-loaded film-forming gels showed good physicochemical stability during storage at 4º for 6 mo. In summary, the developed α-mangostin-loaded film-forming gels are good candidates for topical antiacne treatments.

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