Characterization, Biocompatibility and Biological Properties of Cissampelos pareira Pectin-Based Hydrogel Patch Containing Heliotropium indicum Extract
Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Thanyaburi, Pathum Thani 12130, Thailand
N. Wisidsri, Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Thanyaburi, Pathum Thani 12130, Thailand, E-mail: firstname.lastname@example.org
Cissampelos pareira and Heliotropium indicum have been used as traditional medicine for treating several disorders. Specifically, Cissampelos pareira simply forms a gel without additional compounds which result from mainly pectin sources. In this study, the pectin from Cissampelos pareira was used to develop a hydrogel patch by adding Heliotropium indicum extract. The characterization of pectin-based hydrogel patch and pectin-based hydrogel containing Heliotropium indicum patch was evaluated. The results revealed suitable characterization of pectin-based hydrogel patches in physical and mechanical properties. The pectinbased hydrogel patches also presented biological activities through antioxidant and anti-inflammatory activities and these effects were synergized in a pectin-based hydrogel containing Heliotropium indicum patches. Furthermore, the pectin-based hydrogel patches presented biocompatibility by non-cytotoxicity to fibroblast and macrophage cells. Fibroblasts can proliferate in the pectin-based hydrogel patches. According to the results, the pectin-based hydrogel patches are of great benefit in pharmaceutical and cosmeceutical applications.