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Abstract

Characterization Of Ibuprofen Loaded Microcapsules Prepared By Ionotropic Gelation

Author(s): A. P Kakkar

Calcium-induced freeflowing, spherical, smooth surfaced alginate microcapsules of ibuprofen were prepared by lonotropic gelation method. The preparation is based on dispersion of sodium alginate ibuprofen mixture in liquid paraffin followed by incurring coating process by calcium chloride as curing agent. Sodium alginate concentrations influenced the mean diameter, recovery, encapsulation efficiency, wall thickness, size distribution and release characteristics of the microcapsules. SEM, Polarizing microscopy, powder x-ray analysis and IR spectral analysis of microcapsules were also conducted.

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