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Ciprofloxacin Prodrug Via Mannich Reaction

Author(s): Suraj P Agarwal, Honey Bala, Mushir M Ali

A prodrug of ciprofloxacin was prepared using Mannich reaction, refluxing ciprofloxacin as amine component with p-hydroxyacetophenone and aqueous formaldehyde in 1,2-dimethoxyethane for 30 h. the prodrug (mp.230-232°) had increased solubility and dissolution rate over the parent drug. The pH-rate profile and in vitro antimicrobial activity of the prodrug were also studied.


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Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report