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Abstract

Clinical Effect of Evjiv Combined with Oral Lipoic Acid on Patients with Diabetic Foot

Author(s): Ying Zhou*, Ming Zhen Li and Zhen Huan Jiang
Department of Diabetic Foot, 1Depatment of Gout, 2Depatment of Metabolic Disease, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, No.6 North Huanrui Rd, Beichen District, Tianjin 300134, P. R. China

Correspondence Address:
Ying Zhou, Department of Diabetic Foot, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, No.6 North Huanrui Rd, Beichen District, Tianjin 300134, P. R. China, E-mail: [email protected]


To investigate the clinical effect of the combination of evjiv and oral lipoic acid in the treatment of diabetic foot and its effect of oxidative stress and inflammation is the objective. 100 patients with diabetic foot treated in our hospital from January 2020 to March 2021 were selected and random divided into control group and observation group. Patients in control group were treated with basic treatment regimen and patients in observation group were treated with evjiv combined with oral lipoic acid on the basis of the control group. The treatment effects, oxidative stress indexes and inflammation indexes of the patients in the two groups were compared after treatment. After treatment, the total effective rate of patients in observation group was significantly higher than that in control group. Fasting blood glucose and 2 h postprandial blood glucose of patients in both groups were lower than those before treatment. Serum advanced oxidation protein products and malondialdehyde in observation group were lower than those in control group and superoxide dismutase was higher than that in control group. The vascular cell adhesion molecule-1, fibroblast growth factor 2, tumor necrosis factor alpha and interleukin-6 in both groups were lower than those before treatment. The positive rate of bacterial culture on the sore surface in observation group was significantly lower than that in control group and these difference were statistically significant (p<0.05). The use of lipoic acid combined with evjiv in the early stage of diabetic foot can effectively improve the oxidative stress and inflammation of patients and improve the clinical efficacy.

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