Abstract

To observe the clinical efficacy and safety of tapazole integrated with anti-heart failure drugs in the remedy of hyperthyroidism merged with heart failure. Subjects 39 y~78 y suffered from hyperthyroidism and heart failure were enrolled, a total of 120 subjects were assigned to two subgroups according to different intervention methods. A control subgroup (n=60), which was given anti heart failure drugs intervention, and an observation subgroup (n=60), which was given tapazole intervention on the grounds of the control subgroup. The clinical efficacy, thyroid function, cardiac function, immune function and adverse reactions of the two subgroups were contrasted. In terms of the total effective rate, vs. the control subgroup (76.67 %), the observation subgroup (91.67 %) was notable higher. The concentrations of serum free triiodothyronine 3, free thyroxine 4 and N-terminal pro-brain natriuretic peptide in the observation subgroup were lower, thyroid stimulating hormone and left ventricular ejection fraction, SV, E/A were higher, the increase of cluster of differentiation 3+, cluster of differentiation 4+and cluster of differentiation 4+/ cluster of differentiation 8+ ratio in the observation subgroup was greater and cluster of differentiation 8+ declined more notablely. The remedy of hyperthyroidism and heart failure with tapazole integrated with anti-heart failure drugs is more effective. It can improve the thyroid function and heart function of subjects, enhance the body immunity, and has guaranteed safety.