Abstract

This study analyzed the clinical efficacy, safety and effect on coagulation function of octreotide combined with pantoprazole in the treatment of gastrointestinal bleeding. Analysis was conducted using 82 individuals with gastrointestinal bleeding who were treated in Hangzhou Ninth People’s Hospital from June 2021 to June 2023. They were divided into a single group and combination group according to the actual medication plan. The medication regimen of the single group is pantoprazole, and the medication regimen of the combination group is combination of octreotide and pantoprazole, where the medication cycle is 7 d. The medication effects, inflammatory factor indicators, adverse drug reactions, and coagulation function of the two groups of patients were observed. After treatment, the total effective rate of treatment in the single group was 87.8 %, while in the combined group was found to be 100 % (p<0.05). After medication, the inflammatory factor indicators in both groups were lower than before medication, and even lower in the combination group (p<0.05). During the medication, the incidence of adverse drug reactions in the single group was 7.32 % and in the combination group was 9.76 % (p>0.05). The coagulation function indicators of the latter two groups improved and the combination group was showed better results (p<0.05). For gastrointestinal bleeding, the medication regimen of octreotide+pantoprazole is effective, helps to reduce the patient’s inflammation level and improve the coagulation function.