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Abstract

CNS activity and synthesis of some 4 (3H)- quinazolinones.

Author(s): R Lakhan, RL Singh
Dept. of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 211 005,

Correspondence Address:
R Lakhan Dept. of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 211 005

Synthesis are described for a series of 2-carboylmethylthio and 2-[w. (diamethylaminoalkyl) thio]-3-alkyl (or aryl)-4 (3H)-qinazolinones (I) as the key intermediates. Twelve of the synthetic compounds were tested for their CNS activities in mice and shown to be either CNS depressants of stimulants.

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