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Abstract

CNS Activity Of Petroleum Ether Extract Of Vitex Negundo Linn In Mice

Author(s): Malaya Gupta, U. K Mazumder, Sima Rani Bhawal, S. M. K Swamy

The dried leaves of Vitex negundo was extracted with petroleum ether. The active fraction of the extract was separated by column chromatographic technique, and the Acute toxicity studies were done using Swiss albino mice of either sex. Three dose levels (125, 167, 250 mg/kg b.w.) were chosen to study analgesic, anti-convulsant and sedative-hypnotic activities using Swiss albino mice of either sex. The leaf extract potentiated the sedative-hypnotic effect of pentobarbitone and diazepam significantly (P≤ .001) in a dose dependent manner, while it did not produce sleep in mice itself. The extract showed significant analgesic activity and prolonged the analgesia produced by morphine and pethidine, whereas, the anti-convulsant activity against strychnine and leptazole was found only at high dose levels (250 mg/kg b.w.).

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