Abstract
CNS depressant activity of ethanol extract of Sterculia guttata seeds in mice
Author(s): SR Katade1, AV Misar2, AM Mujumdar2, UD Phalgune3, RD Wakharkar4, NR Deshpande1
1 T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parshurambhau College, Pune-411 030, India 2 Division of Plant Sciences, Agharkar Research Institute, Pune-411 004, India 3 Center for Materials Characterization, National Chemical Laboratory, Pune-411 008, India 4 Organic Chemistry Technology, National Chemical Laboratory, Pune-411 008, India
Correspondence Address:
N R Deshpande T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parshurambhau College, Pune-411 030 India rkatade@hotmail.com
1 T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parshurambhau College, Pune-411 030, India 2 Division of Plant Sciences, Agharkar Research Institute, Pune-411 004, India 3 Center for Materials Characterization, National Chemical Laboratory, Pune-411 008, India 4 Organic Chemistry Technology, National Chemical Laboratory, Pune-411 008, India
Correspondence Address:
N R Deshpande T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parshurambhau College, Pune-411 030 India rkatade@hotmail.com
Shade dried, powdered seeds of Sterculia guttata were extracted using a Soxhlet extractor with ethanol. Ethanol was removed under reduced pressure and dried to obtained crude extract. This extract was evaluated for its effect on behavioral changes, exploratory activity and barbiturate-sleeping time, using appropriate standard methods in mice. The extract exhibited dose-dependent CNS depressant activity.
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