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Abstract

Colon-Specific Drug Delivery Systems

Author(s): S Sarasija, A Hota

Colon specific delivery of drugs are of interest for the treatment of colonic diseases, so as to maximize the effectiveness of these drugs. Oral delivery of peptides and proteins are possible because colon provides a more friendly environment than the upper gastrointestinal tract. Colon is also rich in lymphoid tissue so uptake of antigens into the mast cells of the colonic mucosa produces rapid local production of antibodies thus helping in vaccine delivery. This review deals with the anatomy and physiology of colon and various aspects of formulations by which colon targeting of drugs can be achieved.

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