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Abstract
Colorimetric method for the estimation of escitalopram oxalate in tablet dosage form
Author(s): T Vetrichelvan1, K Arul2, M Sumithra1, B Umadevi1
1 Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319, India 2 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Medical College, Thiruvananthapuram-695 011, India
Correspondence Address:
T Vetrichelvan Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319 India E-mail: vetrisel@yahoo.com
1 Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319, India 2 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Medical College, Thiruvananthapuram-695 011, India
Correspondence Address:
T Vetrichelvan Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319 India E-mail: vetrisel@yahoo.com
A colorimetric method for the analysis of escitalopram oxalate in pure form and in tablets has been developed based on the formation of chloroform soluble ion associates with bromocresol green acidic dye. The extract of ion associates exhibited absorption maxima at 417 nm obeying Beer's law in the range of 2-10 μg/ml. The method is simple, precise and accurate with recovery of 98-102% and does not require any separation of soluble excipients from tablet dosage form.
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