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Abstract

Combinatorial Chemistry

Author(s): K. G Bothara, Ajit D Gaikwad, Atmaja Saxena

A promising new approach to drug discovery concerns with the synthesis and screening of combinatorial libraries in order to identify new compounds that express high affinity and specificity for a pharmacologically relevant, biomolecular target. Advances in molecular biology, automated chemical synthesis and robotics have facilitated the formulation of vast libraries of structurally related molecules. An essential aspect of screening large combinatorial libraries is the ability to identify the active components in these complex mixtures, which is usually based on the strength of binding to a selected target macromolecule.

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