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Abstract

Comparative Bioavaliability Studies Of Some Oral Amoxycillin Capsules

Author(s): M. K Hassanzadeh, A Daneshvari

Relative bioavailability of four brands of amoxycillin capsules were examined. The absorption of each dosage form was compared in a crossover study of thirteen healthy subjects (6 males and 7 females). Plasma concentrations and urinary excretion rates were employed to evaluate the absorption process. Statistical analysis of the results were carried out to evaluate the significance of differences between dosage forms and subjects. The statistical analysis indicated no significant differences between different tested brands of amoxycillin (except for brand A) while the differences between subject were significant. Although the differences between brand A and other brands are significant, the differences, are within the % ± 20 range and is not clinically important. Comparison between the two different genders indicated no significant differences between the male and female subjects.

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