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Abstract

Comparative Study of Montelukast and Mometasone Furoate in the Treatment of Pediatric Obstructive Sleep Apnea Syndrome

Author(s): B. Xing, Chucheng Wu, Y. Zhu and J. Wang*
Department of Otorhinolaryngology, South China Hospital of Shenzhen University, Shenzhen, Guangdong Province 518060, China

Correspondence Address:
J. Wang, Department of Otorhinolaryngology, South China Hospital of Shenzhen University, Shenzhen, Guangdong Province 518060, China, E-mail: jiaoba291209@163.com


This study aimed to compare the efficacy of combined treatment with kenacort and montelukast vs. surgical treatment using low temperature plasma radiofrequency ablation in children with snoring. 70 children with snoring were selected as the study subjects at our hospital and all children met the inclusion criteria. According to the different treatments received by the children, the control group (n=35) received combined treatment with kenacort and montelukast, while the observation group (n=35) underwent surgery (low temperature plasma radiofrequency ablation). The clinical treatment effects, degree of adenoid hypertrophy, symptom improvement, ventilator function, sleep quality and quality of life were compared between the two groups of children. The total effective rate of treatment in the control group was 71.43 %, while that in the observation group was 94.29 %, which was significantly higher than that in the control group (p<0.05). Before treatment, there was no significant difference in the adenoid-nasopharyngeal ratio between the two groups (p>0.05). After treatment, the adenoidnasopharyngeal ratio in the observation group was significantly lower than that in the control group (p<0.05). Before treatment, there was no significant difference in the symptom score between the two groups (p>0.05). After treatment, the symptom score in the observation group was significantly lower than that in the control group (p<0.05). Before treatment, there was no significant difference in the LAT, oxygen desaturation index 4 % and apnea-hypopnea index levels between the two groups (p>0.05). After treatment, the LAT, oxygen desaturation index 4 % and apnea-hypopnea index levels in the observation group were significantly lower than those in the control group (p<0.05). Before treatment, there was no significant difference in the Pittsburgh sleep quality index score and obstructive sleep apnea-1 score between the two groups (p>0.05). After treatment, the Pittsburgh sleep quality index score and obstructive sleep apnea-1 score in the observation group were significantly lower than those in the control group (p<0.05). Compared with combined treatment with kenacort and montelukast, low-temperature plasma radiofrequency ablation is more effective for children with snoring and surgical treatment can better improve the clinical symptoms and ventilator function of children, thereby further improving their sleep quality and quality of life.

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