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Comparison of Clinical Effects of Intravenous Tranexamic Acid and Carbetocin in the Treatment of Postpartum Hemorrhage

Author(s): Xiaoling Zeng, Dan Huang*, Xin Luo, Han Gong and X. X. Wang
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangdong, Guangzhou 510632, 1Department of Obstetrics, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China

Correspondence Address:
Dan Huang, Department of Obstetrics, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China, E-mail:

Postpartum hemorrhage is one of the main causes of maternal death. This study compares clinical efficacy and adverse reactions rate between tranexamic acid injection and carbetocin in postpartum hemorrhage treatment. We selected 80 cases of postpartum hemorrhage after vaginal delivery who received therapy in the Affiliated Hospital of Guizhou Medical University from January 2019 to June 2020. And then randomly divided them into experiment group (40 cases receiving carbetocin treatment) and control group (40 cases receiving intravenous tranexamic acid treatment), compared the blood routine and coagulation function of both groups before and after treatment, and compared the postoperative clinical efficacy, blood pressure, heart rate and adverse reactions. The clinical efficiency of experimental group (95 %) was remarkably higher than control group (85 %) (p<0.05); experimental group had remarkably lower postpartum blood loss and hemoglobin reduction than control group (p<0.05); adverse reactions rate in experimental group (5 %) was remarkably lower than control group (17.5 %) (p<0.05). And after treatment heart rate of experimental group remarkably increased more than control group, so it possessed statistical significance (p<0.05). It had no obvious divergence in coagulation function (prothrombin time, activated partial prothrombin time, fibrinogen) and blood pressure between both groups before and after treatment, and it possessed no statistical significance (p>0.05). Carbetocin has a better clinical effect than tranexamic acid injection in postpartum hemorrhage treatment. It can effectively reduce postpartum blood loss. The clinical effect is greater and adverse reactions rate is less than that of tranexamic acid, which is worth popularizing in clinic.

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