All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Comparison of Propranolol and Metoprolol on Patients with Unstable Angina Pectoris and their Effects on High-Sensitivity C-Reactive Protein, Lipoprotein Associated Phospholipase A2

Author(s): B. Zhang, J. Zhou*, Wenjing Dai, J. Lv and Yuanlin Guo
Department of Internal Cardiovascular Medicine, Renhe Hospital, China Three Gorges University, Yichang, Hubei 443000, China

Correspondence Address:
J. Zhou, Department of Internal Cardiovascular Medicine, Renhe Hospital, China Three Gorges University, Yichang, Hubei 443000, China, E-mail: [email protected]


To investigate the efficacy of propranolol and metoprolol on unstable angina pectoris patients and their effects on high-sensitivity C-reactive protein and lipoprotein associated phospholipase A2. Altogether 138 unstable angina pectoris patients admitted to our hospital were considered and enrolled into two groups in view of the treatment methods. Among them, 62 patients in the control group were treated with propranolol and 76 cases in the observation group were treated with metoprolol. The efficacy and incidence of adverse reactions of patients after treatment in both groups were recorded, and their seizure frequency and duration of angina pectoris were compared. The cardiac functions of both groups before and after treatment were compared: left ventricular ejection fraction, left ventricular end diastolic volume and left ventricular end systolic volume. Enzyme-linked immunosorbent assay was employed to examine the concentration of inflammatory factors in serum before and after treatment: serum high-sensitivity C-reactive protein and serum lipoprotein-associated phospholipase A2. The risk factors affecting their efficacy were assessed through logistic regression analysis. The expression of cardiac function in the observation group after treatment was dramatically better than that in the control group. The seizure frequency, duration and inflammatory factor level in the observation group after treatment were dramatically lower than those in the control group. The clinical efficacy in the observation group was obviously higher than that in the control group. There was no marked difference in incidence of adverse reactions between both groups. Multivariate logistic regression analysis identified that gender, history of diabetes, hypertension, levels of high-sensitivity C-reactive protein, lipoprotein associated phospholipase A2 before treatment and treatment methods were independent risk factors affecting their efficacy. Compared with propranolol, metoprolol can dramatically improve the cardiac function of unstable angina pectoris patients, control the seizure frequency and duration of angina pectoris and reduce the level of inflammatory factors.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report