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Correlation of Long Non-Coding RNAs Taurine Up-Regulated Gene 1 with Clinicopathological Features in Patients with Ear Canal Cholesteato ma and on Its Expression Change under Anti-Infective Drugs

Author(s): Ting Xu, Haili Zhang*, Shuiling Xiong, C. Shi and Huijuan Fan
Department of Otolaryngology-Head and Neck Surgery, Shanxi Medical University, Xinjian Taiyuan, Shanxi 030001, China

Correspondence Address:
Haili Zhang, Department of Otolaryngology-Head and Neck Surgery, Shanxi Medical University, Xinjian Taiyuan, Shanxi 030001, China, E-mail:

To analyze long non-coding RNAs taurine up-regulated gene 1 expression in middle ear cholesteatoma and its correlation with the degree of ossicle destruction. Sixty four patients with middle ear cholesteatoma admitted to our hospital from June 2019 to December 2020 were selected as the research participants for retrospective analysis. Middle ear cholesteatoma tissue and normal skin of the external auditory canal were obtained to determine taurine up-regulated gene 1 expression. Correlations of taurine up-regulated gene 1 with clinicopathological features and ossicle destruction as well as clinical efficacy were discussed. Moreover, patients were followed up for 1 y to observe taurine up-regulated gene 1’s impacts on disease recurrence. Taurine up-regulated gene 1 expression level increased in middle ear cholesteatoma tissue (p<0.001), was strongly linked to the course of disease, history of ear canal diseases and pathological staging (p<0.001). Taurine up-regulated gene 1 increased obviously in patients with complete ossicle destruction and decreased in patients with intact ossicles (p<0.001). Pearson correlation coefficient revealed a positive connection between taurine up-regulated gene 1 and the ossicle destruction score (r=0.791, p<0.001). Taurine up-regulated gene 1 was the lowest in the cured patients and was higher in ineffective patients than in improved patients (p<0.05). Spearman correlation coefficient identified an inverse connection between taurine up-regulated gene 1 and therapeutic efficacy. Patients were given with amoxicillin clavulanate potassium and prednisone after surgery and taurine up-regulated gene 1expression was significantly decreased by these anti-infection drugs. Taurine up-regulated gene 1 also increased in patients with recurrence during prognostic follow-up, with a sensitivity of 81.82 % and specificity of 86.00 % for predicting the 1 y recurrence in patients (p<0.001). Taurine up-regulated gene 1 is elevated in middle ear cholesteatoma and is closely linked to ossicle destruction in patients, which may be a breakthrough in diagnosing and treating middle ear cholesteatoma in the future.

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