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Degradation of some aqueous semi-synthetic penicillin solutions in presence of copper (II) ions.

Author(s): NR Chatterjee, MS Degani, CB Singh
Hindustan Antibiotics Research Centre, Pimpri, Pune 411 018,

Correspondence Address:
N R Chatterjee Hindustan Antibiotics Research Centre, Pimpri, Pune 411 018

Degradation of aqueous solution of several semi-synthetic penicillins viz. ampicillin, hetacillin, phthalimido penicillin as well as sulfoxides of benzylpenicillin, phthalimide penicillin and ampicillin, in presence of copper (II) ions has been studied following UV-visible spectrophotometric method. Based on these results, comparative studies have been made to evaluate the role of metal ion in affecting the two major pathways responsible for penicillin degardation.


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