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Design and development of mixed film of pectin: Ethyl cellulose for colon specific drug delivery of sennosides and Triphala

Author(s): Munira Momin1, K Pundarikakshudu1, SA Nagori2
1L. J. Institute of Pharmacy, Sanand Cross Road, Sarkhej Gandhinagar Highway, Ahmedabad-382 210, India 2L. M. College of Pharmacy, Navarngpura, Ahmedabad-380 009, India

Correspondence Address:
Munira Momin L. J. Institute of Pharmacy, Sanand Cross Road, Sarkhej Gandhinagar Highway, Ahmedabad-382 210 India E-mail: [email protected]

The present study was aimed at developing colon specifi c drug delivery system for sennosides and Triphala. These drugs are reputed Ayurvedic medicines for constipation in India. The proposed device explored the application of pectin and ethyl cellulose as a mixed fi lm for colon specifi c delivery. This mixed fi lm was prepared using non-aqueous solvents like acetone and isopropyl alcohol. A 32 factorial design was adopted to optimize the formulation variables like, ratio of ethyl cellulose to pectin (X1) and coat weight (X2). The rate and extent of drug release were found to be related to the thickness and the ratio of pectin to ethyl cellulose within the fi lm. Statistical treatments to the drug release data revealed that the X1 variable was more important than X2. Under simulated colonic conditions, drug release was more pronounced from coating formulations containing higher proportions of pectin. The surface of the device was coated with Eudragit S100 to ensure that the device was more pH dependent and trigger the drug release only at higher pH. The fi nal product is expected to have the advantage of being biodegradable and pH dependant. This type of a fi lm effectively releases the drug while maintaining its integrity.

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