Abstract
Design And Evaluation Of Chitosan Microspheres Of Metoprolol Tartrate For Sustained Release
Metoprolol tartrate was formulated as biodegradable microspheres using chitosan by the phase separation emulsification technique. Microspheres of 1:0.5, 1:1 and 1:2 drugs to carrier ratios were prepared and thermally cross-linked. Drug to carrier ratio 1:1 showed maximum percentage yield and highest drug entrapment. The size range of the microspheres varies from 3.5 to 31.5 pm. UV and DSC studies were carried out to confirm the presence and stability of the drug in the microspheres. Short-term stability studies were carried out at different temperatures. In vitro release studies were carried out at different pH for a period of 10 h and compared with the pure drug. The release of rnetoprolol tartrate from the chitosan microspheres was found to be sustained.
