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Design And Evaluation Of Mucoadhesive Baccal Films Of Diltiazem Hydrochloride

Author(s): A Semalty, Mona Bhojwani, G. K Bhatt, G. D Gupta, A. K Shrivastava

Mucoadhesive buccal films of diltiazem hydrochloride were prepared by solvent casting technique using sodium carboxymethylcellulose, polyvinyl pyrrolidone K-30 and polyvinyl alcohol. Prepared films were evaluated for their weight, thickness, surface pH, swelling index, in vitro residence time, folding endurance, in vitro release, permeation studies and drug content uniformity. Films exhibited controlled release over more than 6 h. From this study it was concluded that the films containing 20 mg diltiazem hydrochloride in polyvinyl alcohol 10% and polyvinyl pyrrolidone 1% w/v (formulation F5), showed moderate swelling, a convenient residence time and promising drug release, thus can be selected for the development of buccal film for potential therapeutic uses.


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