All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Design and evaluation of mucoadhesive buccal drug delivery systems containing metoprolol tartrate

Author(s): MV Ramana, C Nagda, M Himaja
Department of Pharmaceutics, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Mangalore - 575 005, India

Correspondence Address:
M V Ramana Department of Pharmaceutics, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Mangalore - 575 005 India E-mail: dr_ramanamv@yahoo.com


Mucoadhesive buccal tablets of metoprolol tartarate were fabricated with objective of avoiding first pass metabolism and prolonging duration of action. The mucoadhesive polymers used in formulation were Carbopol-934, hydroxypropylmethylcellulose, hydroxyethylcellulose and sodium carboxymethylcellulose. The formulations were characterized for physiochemical parameters, in vitro release studies and in vivo placebo studies. The best mucoadhesive performance and in vitro drug release profile were exhibited by the tablets containing hydroxyethylcellulose and Carbopol-934 in ratio 1:2. This product was more comfortable to the user due to absence of erosion, faster hydration rate and less viscosity of surrounding environment. In vivo placebo studies did not show any side effects.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report