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Design And Evaluation Of Mucoadhesive Buccal Patches Of Diclofenac Sodium

Author(s): J.S Patil, K.P Rao

The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of diclofenac sodium, which is used as analgesic and antiinflammatory agent. Patches were fabricated by casting technique with different polymer combinations and were evaluated for in vitro release, bio-adhesion strength, duration of bioadhesion, folding endurance, surface pH and percentage of elongation. The release profile and test for adhesion were found to be the function of the type of polymer used. The formulation containing hydroxy propyl cellulose and carbapol 934 P was found to give the better results.


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