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Design and synthesis of some novel 4-(4-substituted aryl) semicarbazones as anticonvulsant agents

Author(s): Anita Singh1, C Pande1, P Gahtori1, SN Pandeya2, JP Stables3
1 Department of Pharmacy, Kumaun University, Bhimtal-263 002, India 2 Saroj institute of Pharmacy, Lucknow-222 001, India 3 Epilepsy Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA

Correspondence Address:
Anita Singh Department of Pharmacy, Kumaun University, Bhimtal-263 002 India E-mail: [email protected]

In the present study, a series of 4-(4-substituted aryl) semicarbazones were synthesized from substituted anilines and subsequently evaluated for their anticonvulsant activities. The anticonvulsant activities were established by the anticonvulsant drug development (ADD) programme NIH, USA using experimental animal, adult male FCM mice (20-25 g) and adult Sprague-Dawley rats (100-150 g) and screened against electroshock seizure, subcutaneous metrazole and minimal neurotoxicity tests in mice. Compound 7 was found equipotent to carbamazepine in both MES and ScPTZ tests. This study has highlighted the importance of distal alkyl chain which influences the anticonvulsant activity.

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