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Abstract

Development And Evaluation Of Antifungal Activity Of O/W Type Creams Containing Solid Dispersion Of Clotrimazole

Author(s): B Madhusudhan, D Rambhau, V. R Gudsoorkar, J. S Shete, S. S Apte

Clotrimazole (CLTZ) solid dispersions of various compositions were prepared by melting or melt-solvent methods using mannitol as carrier. Cream base of O/W type was prepared by emulsification method and the solid dispersion were incorporated in cream base by trituration. The in vitro antifungal activity of CLTZ solid dispersion creams were estimated using the test organism Candida albicans. The interaction of sulphamethoxazole (SMZ) with CLTZ in the form of solid dispersion creams were also estimated for their antifungal activity. improved antifungal activity was found with CLTZ solid dispersions. However, there was no significant improvement in the activity in presence of SMZ.

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