All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Development and evaluation of oral controlled release chlorpheniramine-ion exchange resinate suspension

Author(s): AU Kadam, DM Sakarkar, PS Kawtikwar
S. N. Institute of Pharmacy, Pusad, Dist. Yavatmal-445 204, India

Correspondence Address:
A U Kadam S. N. Institute of Pharmacy, Pusad, Dist. Yavatmal-445 204 India E-mail: [email protected]

An oral controlled release suspension of chlorpheniramine maleate was prepared using ion-exchange resin technology. A strong cation exchange resin Indion 244 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug-resinate complex was microencapsulated with a polymer Eudragit RS 100 to further retard the release characteristics. Both the drug-resinate complex and microencapsulated drug resinate were suspended in a palatable aqueous suspension base and were evaluated for controlled release characteristic. Stability study indicated that elevated temperature did not alter the sustained release nature of the dosage form indicating that polymer membrane surrounding the core material remained intact throughout the storage period.

Full-Text | PDF

Google scholar citation report
Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report