All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Development and validation of a spectrofluorimetric method for the estimation of rivastigmine in formulations

Author(s): R Kapil, S Dhawan, Bhupinder Singh
University Institute of Pharmaceutical Sciences (UGC Centre of Advanced Studies) Panjab University, Chandigarh-160 014, India

Correspondence Address:
Bhupinder Singh University Institute of Pharmaceutical Sciences (UGC Centre of Advanced Studies) Panjab University, Chandigarh-160 014 India [email protected]


A rapid, sensitive, simple, and cost-effective spectrofluorimetric method was developed for the estimation of rivastigmine in bulk and pharmaceutical formulations. The relative fluorescence intensity of rivastigmine was measured in triple distilled water at an excitation wavelength of 220 nm and an emission wavelength of 289 nm. Linearity range was found to be 100 to 4000 ng/ml. The method was validated for various parameters as per the ICH guidelines and USP requirements. The detection and quantitation limits were found to be 20.5 and 62.1 ng/ml, respectively. The results demonstrate that the procedure is accurate, precise, and reproducible, while being simple and rapid too. The results were found to be in good agreement with the label claims.

Full-Text | PDF