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Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium

Author(s): RN Haddadin, AY Issa

A simple and inexpensive titrimetric method for the determination of magnesium ion in esomeprazole magnesium raw material was developed and validated according to International Conference on Harmonization guidelines and the United States Pharmacopoeia. The method depends on complex formation between EDTA and magnesium ion. The method was proven to be valid, equivalent and useful as an alternative method to the current pharmacopeial methods that are based on atomic absorption spectrometry.

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