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Development of fast dispersible aceclofenac tablets: Effect of functionality of superdisintegrants

Author(s): C Mallikarjuna Setty1, D.V.K Prasad1, V.R.M Gupta1, B Sa2
1Department of Pharmaceutics, N.E.T. Pharmacy College, Raichur-584 103, India 2Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India

Correspondence Address:
C Mallikarjuna Setty Department of Pharmaceutics, N.E.T. Pharmacy College, Raichur-584 103 India E-mail: [email protected]

Aceclofenac, a non-steroidal antiinflammatory drug, is used for posttraumatic pain and rheumatoid arthritis. Aceclofenac fast-dispersible tablets have been prepared by direct compression method. Effect of superdisintegrants (such as, croscarmellose sodium, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, in vitro release and stability parameters has been studied. Disintegration time and dissolution parameters (t 50% and t 80% ) decreased with increase in the level of croscarmellose sodium. Where as, disintegration time and dissolution parameters increased with increase in the level of sodium starch glycolate in tablets. However, the disintegration time values did not reflect in the dissolution parameter values of crospovidone tablets and release was dependent on the aggregate size in the dissolution medium. Stability studies indicated that tablets containing superdisintegrants were sensitive to high humidity conditions. It is concluded that fast-dispersible aceclofenac tablets could be prepared by direct compression using superdisintegrants.

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