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Differential Expression of ANXA2 in Eutopic and Ectopic Endometrium

Author(s): Haiyan Yu, Qingling Lu1, Yiting Wang1, X. Ma, Bo Li1 and Lina Yang1*
Health Management Center, 1Department of Gynecology, Heilongjiang Provincial Hospital, Harbin City, 150036, Heilongjiang Province, China

Correspondence Address:
Department of Gynecology, Heilongjiang Provincial Hospital, Harbin City, 150036, Heilongjiang Province, China, E-mail:

The purpose of this study was to compare the differences in expression of annexin A2, ANXA2 between eutopic and ectopic endometria and to explore the pathogenesis of adenomyosis. In this study, 22 adenomyosis patients who underwent uterine laparotomy in Heilongjiang Provincial Hospital from April 2016 to October 2018 were enrolled as the observation group. The eutopic and ectopic endometria were used for the experiment. In addition, 22 uterine fibroids patients with normal endometrium who underwent open hysterectomy were selected as the control group. The levels of ANXA2 in endometrial tissue and serum were compared between the two groups. The results showed that the ANXA2 level in normal endometrial tissue was significantly lower than that in the eutopic and ectopic endometrial tissue and the ANXA2 level in the ectopic endometrium was significantly higher than that in the eutopic endometrium (p<0.05). The ANXA2 level in the serum of the observation group was significantly (p<0.05) higher than that of the control group. Clinical monitoring of changes in ANXA2 level could be useful as auxiliary diagnostic marker to start treatment of adenomyosis, so as to project prognostic changes more accurately. However, the results of this study still need to be verified with multi-center samples.

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