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Dissolution development of valdecoxib tablets

Author(s): G Subramanian, M Faisal, A Karthik, V Bhat, A Ranjithkumar, N Udupa
Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104, India

Correspondence Address:
N Udupa Manipal College of Pharmaceutical Sciences, MAHE, Manipal-576 104 India E-mail:

Valdecoxib is a nonsteroidal antiinflammatory drug, and it is listed in class 2 of biopharmaceutic classification of drugs. Valdecoxib is a poorly water-soluble and highly permeable drug. In the present study a new dissolution medium was developed, as there is no official dissolution medium available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37°. Solubility data revealed that addition of surfactant may be suitable as dissolution medium. The concentration of 0.6% w/v sodium lauryl sulphate in water could be a suitable dissolution medium. The discriminating power of the selected dissolution medium (0.6% sodium lauryl sulphate in water) relative to the other dissolution mediums was evaluated. The selected dissolution medium was used for the evaluation of valdecoxib tablets.

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