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Diuretic and antibacterial activity of aqueous extract of Cleome rutidosperma D.C.

Author(s): A Bose1, JK Gupta2, GK Dash1, T Ghosh1, S Si1, DS Panda1
1 Institute of Pharmacy and Technology, Salipur, Cuttack - 754 202, India 2 Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, India

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A Bose Institute of Pharmacy and Technology, Salipur, Cuttack - 754 202 India E-mail:

Crude aqueous extract of Cleome rutidosperma was investigated for diuretic and antibacterial activity. The diuretic activity was tested in rats at 400 and 600 mg/kg, orally and compared with furosemide (20 mg/kg, intraperitoneally) as the standard. The antibacterial activity was assessed by disc diffusion method against Bacillus subtilis , Bacillus laterosporus , Staphylococcus aureus , Micrococcous luteus, Pseudomonas aeruginosa , Vibrio cholerae , Escherichia coli and Salmonella typhi at concentrations of 100, 200 and 400 µg/disc respectively. Ciprofloxacin (5 µg/disc) was used as reference control for the antibacterial study. The extract was found to possess significant dose dependent diuretic activity and also effective against both gram-positive and gram-negative bacteria in a concentration dependent manner.

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