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Drug Release From Terbutaline Sulphate Transdermal Films Across Human Cadaver Skin

Author(s): S Narasimha Murthy, Mini Sateesh, V Hamsa

Transdermal films of Terbutaline Sulphate were formulated as mololithic matrices using cellulose polymers like Hydroxy propylmethyl cellulose (HPMC), Sodium Carboxy methyl cellulose (Sod, CMC), Cellulose acetate and Ethyl cellulose. In vitro diffusion studies were carried out across isolated stratum corneum of fresh human cadaver skin, using keshary-Chien type diffusion cell. Skin irritancy test was carried out on human volunteers. The formulations were subjected to stability studies at different temperatures. The films were found to be stable at all temperature conditions. The human volunteers did not show any signs of erythema and oedema. The formulations showed an appreciable release after eight hours.


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