Abstract

The main objective of this study was to determine the effect, safety and intestinal microecology of amoxicillin-clavulanate potassium, ceftriaxone combined with pulmonary physical therapy on neonatal pneumonia. A total of 180 neonatal pneumonia patients in our hospital were studied and divided into research group (n=90) and control group (n=90). The control group was treated with amoxicillin-clavulanate potassium and ceftriaxone and the study group was treated with pulmonary physiotherapy on the basis of control group. The treatment cycle was 7 d. The two groups were compared with total response rate, symptom resolution time, lung function index, inflammatory factor index, adverse reactions and the number of major probiotics in the intestine. The total effective rate of the research group was significantly higher than that of the control group, the symptom disappearance time of the research group was shorter than that of the control group and the lung function index was better than that of the control group. The inflammatory factor index, the incidence of adverse reactions was lower than that of the control group and the main probiotics in the intestinal tract of the research group was more than that of the control group (p<0.05). For neonatal pneumonia, on the basis of amoxicillin-clavulanate potassium and ceftriaxone, supplemented with pulmonary physical therapy, the effect is better, the safety is high and it can improve the lung function level of patients, reduce the level of inflammatory factors and balance the gut microbiome.