All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Effect of 5-Aminolevulinic Acid Photodynamic Therapy Combined with Carbon dioxide Laser on Condyloma Acuminatum

Author(s): Xiaolei Xie, Huajie Zhong, Shunli Tang, Yuan Wu, Xue Xu and Cong Zhu*
Department of Dermatology, 1Department of General Surgery, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Zhejiang 313000, China

Correspondence Address:
Cong Zhu, Department of General Surgery, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Zhejiang 313000, China, E-mail: zhucong1605@126.com


By comparing 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser and carbon dioxide laser therapy only, to explore the therapeutic effect of 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser on perianal and anal canal condyloma acuminatum. A total of 74 patients with perianal and anal canal condyloma acuminatum who were admitted to our hospital from January 2021 to December 2021 were selected as the research objects. They were randomly assigned to the observation group and the control group, with 37 cases in each group. The observation group was treated with 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser and the control group was treated with carbon dioxide laser therapy. Both groups were treated once a week for 3 w. The therapeutic effect, recurrence rate and adverse reactions were compared between the two groups. The cure rate of condyloma acuminatum in the observation group was 86.48 %, which was higher than 54.05 % in the control group, with statistical significance (p<0.05). After follow-up, it was found that the recurrence rate of the observation group (13.51 %) was significantly lower than that of the control group (43.24 %), with statistical significance (p<0.05). The incidence of superficial scar and perianal pain in the observation group was 27.03 % and 21.62 % respectively, which was not significantly different from 35.14 % and 29.73 % in the control group. 5-aminolevulinic acid photodynamic therapy combined with carbon dioxide laser in the treatment of perianal and anal canal condyloma acuminatum has the advantages of good curative effect and low r ecurrence rate, which is worthy of clinical pr omotion.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report