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Abstract

Effect of Acupuncture Combined with Butylphthalide Injection on Motor Function and Cognitive Function in Cerebral Infarction

Author(s): Ning Luo, Lianxia Zou, Kui Zhao and Zike Liu*
Department of Pharmacy, 1Department of Traditional Chinese Medicine, Shenzhen Hospital of Beijing University of Chinese Medicine, Longgang, Shenzhen 518172, 2Department of Pharmaceutics, Shenzhen People???s Hospital, Longgang, Shenzhen 518020, 3Department of Pharmaceutics, Shenzhen Hospital of Beijing University of Chinese Medicine, Longgang, Shenzhen 518172, China

Correspondence Address:
Zike Liu, Department of Pharmaceutics, Shenzhen Hospital of Beijing University of Chinese Medicine, Longgang, Shenzhen 518172, China, E-mail: liuzike78@163.com


To investigate the effect of acupuncture combined with butylphthalide injection on motor function and cognitive function and the expression of microRNAs in patients with cerebral infarction. 106 patients with acute cerebral infarction were randomly divided into control group and combined group. The patients in the control group were treated with routine and butylphthalide injection. The patients in the combined group were treated with acupuncture on the basis of the control group. Fugl Meyer scale was used to evaluate the changes of motor function before and after treatment. Mini mental state examination was used to evaluate the changes of cognitive function before and after treatment. Quantitative real-time polymerase chain reaction was used to detect the expression of microRNAs before and after treatment. After treatment, the Fugl Meyer scale score and total score of mini mental state examination scale of the two groups were significantly increased. Compared with the control group, the Fugl Meyer scale score and the total score of mini mental state examination scale in the combined group were significantly higher after treatment. After treatment, the expression of microRNA-92a, microRNA-217, microRNA-221, microRNA-222, microRNA-15a and microRNA-126 decreased significantly, and the expression of microRNA-200, microRNA-182, microRNA-429 and microRNA-497 increased significantly. After butylphthalide injection combined with acupuncture treatment, the expression of microRNA-92a, microRNA-217, microRNA-221 and microRNA-15a in serum decreased further, and the expression of microRNA-182 and microRNA-429 increased further. Acupuncture combined with butylphthalide injection can effectively improve motor function and cognitive function in patients with cerebral infarction, which may be related to the content of microRNA in serum.

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