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Abstract

Effect Of Azadirachta Indica Leaf Extract On Carbontetrachloride - Induced Hepatic Damage In Albino Rats

Author(s): A. M Mujumdar, Anuradha S Upadhye, A. M Pradhan

The shade dried leaves of Azadirachta indica were extracted successively by petroleum ether (60-80o) and ethanol. The ethanol extract after removal of solvent was studied for carbontetrachloride induced hepatic changes using 0.5 g and 1 g/kg oral dose in albino rats. The changes were assessed by serum enzyme profile that include glutamic oxaloacetate transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase (AP), bilirubin (B) and hepatic triglycerides (HTG) levels, histological changes in liver and pentobarbitone sleeping time as a functional parameter. There was significant reversal of biochemical, histological and functional changes induced by carbon tetrachloride in rats by ethanol extract treatment.

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