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Abstract

Effect of Dexmedetomidine on Children Undergoing Craniocerebral Surgery: a Meta-analysis

Author(s): H. Wang, R. Liu1, L. Wu2*, H. Xu3 and T. Xu*
Department of Emergency Medicine, Affiliated Hospital of Xuzhou Medical University, 1Department of General Surgery, Xuzhou Central Hospital Affiliated to Medical School of Southeast University 2Department of Anesthesiology, Xuzhou Municipal Hospital Affiliated with Xuzhou Medical University, 3Department of Anesthesiology, Xuzhou Cancer Hospital, Xuzhou, 221000, Jiangsu, China

Correspondence Address:
Department of Emergency Medicine, Affiliated Hospital of Xuzhou Medical University, China, E-mail: [email protected]

The choice of premedication is vital in pediatric anesthesia. The aim of this study was to assess the effect of dexmedetomidine on the perioperative period of craniocerebral operation in children. Studies were identified by searching mainstream databases from August 2013 to August 2016 .The assessed outcomes included heart rate, mean arterial pressure, NSE, S100β protein, AV-DO2 and CO2ER. The Cochrane risk biased evaluation tool was used to evaluate the quality of the included literature, and the relevant valid data were extracted. Meta analysis was performed using RevMan 5.3 software. Nine randomized controlled trials and observational studies involving 372 patients were included. The results indicated that children with craniocerebral surgery perioperative who were applicated with dexmedetomidine, the heart rate decreased significantly than the control group (weighted mean difference= -22.72, 95 % CI confidence intervals (-39.2, -6.19), p=0.007), NSE were also decreased (weighted mean differences= -5.14, 95 % confidence intervals (-8.24 -2.03), p=0.001). Moreover, there were significant differences in terms of S100β and mean arterial pressure as well. Current evidence indicates that dexmedetomidine can increase cerebral hemodynamic stability, reduce the cerebral oxygen metabolism rate, decrease NSE and S100 protein in children undergoing craniocerebral surgery. Dexmedetomidine played a significant role in brain protection, which was ideal choice of adjuvant treatment in the perioperative period of craniocerebral operation in children.

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