Abstract

To explore the effect of different ovulation induction regimens on pregnancy outcome of patients with endometriosis and infertility treated with in vitro fertilization and transplantation. From December 2016 to December 2019, a total of 324 patients with endometriosis and infertility were selected as subjects. After the same in vitro fertilization treatment, three protocols (super long protocol, modified long protocol and antagonist protocol) were studied retrospectively. Baseline, total Gonadotropin dosage, Gonadotropin days, Luteinizing hormone, progesterone and follicle stimulating hormone levels (U/L), oocyte retrieval and embryo status, clinical pregnancy rate, live birth rate and abortion rate were compared among the three groups. The total number of days and total amount of Gonadotropin in the super long protocol group were lower than those in the modified long protocol group and antagonist group (p<0.05). The progesterone level before oocyte retrieval was the lowest in the modified long protocol group, followed by the super long protocol group, and the highest in the antagonist group (p<0.05). The number of retrieved oocytes, mature oocytes and normal cleavage in the modified long protocol group were significantly higher than those in the super long protocol group (p<0.05), but there was no significant difference in the number of excellent embryos (p>0.05). In addition, the number of retrieved ovums, mature ovums, normal cleavage and excellent embryos in the modified long protocol group was the highest (p<0.05), followed by the super long protocol group (p<0.05). Compared with the other two groups, the pregnancy rate and live birth rate were significantly increased (p<0.05) and the abortion rate was significantly decreased (p<0.05). Finally, the pregnancy rate, live birth rate and abortion rate of the modified long protocol group were higher than those of the antagonist protocol group. The pregnancy rate and live birth rate of super long protocol were higher than those of modified long protocol and antagonist protocol and the abortion rate was lower. The total number of Gonadotropin days and the total amount of Gonadotropin in super long protocol group were lower, which had the advantages of clinical significance. It was a kind of ovulation induction formula worthy of promotion for patients with endometriosis and infertility casen.