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Effect Of Dispersant On The Dissolution Of Chloramphenicol From A Capsule Formulations

Author(s): S Durga Prasad

The effect of Sodium Starch Glycolate (SSG), a dispersant on the dissolution of chloramphenicol from capsules was studied. Chloramphenicol was formulated into capsules with SSG and the capsules were evaluated for drug content, disintegration time and dissolution rate. Marked increase in the dissolution of chloramphenicol was observed when SSG was included in the capsule formulation. This formulation gave fast and rapid dissolution of chloramphenicol fulfilling the USP 23 and B.P. 1993 dissolution requirement.


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